CLONALITY ANALYSIS AND IDH1 AND IDH2 MUTATION DETECTION IN BOTH COMPONENTS OF DEDIFFERENTIATED CHONDROSARCOMA, IMPLICATED ITS MONOCLONAL ORIGIN

Clonality analysis and IDH1 and IDH2 mutation detection in both components of dedifferentiated chondrosarcoma, implicated its monoclonal origin

Dedifferentiated chondrosarcoma (DDCS) is a highly malignant tumor that belongs to an uncommon subtype of chondrosarcoma with a poor prognosis.Microscopically, it is composed of highly differentiated chondrosarcoma and highly malignant noncartilaginous sarcomas with an abrupt interface.The question of whether the two components originated from the

read more

Metabolic syndrome and chronic urticaria

We have read the original article entitled: "Quality of life in chronic urticaria and its relationship with the economic impact and control of the disease in patients treated at the University Hospital of Monterrey, Mexico", by Arias-Cruz et al.In this interesting article, the authors found that 72.2% of patients with chronic urticaria is obese and

read more


Persecutory policies against Roma in Nazi Germany

The article provides an analysis of the persecution measures against the Roma in Nazi Germany, identifying what measures were taken and, in particular, Baby Rattle what tragic consequences they led to on a practical level.The article comparatively analyzes various aspects of the persecution of Roma in Germany, and indeed throughout Europe, precedin

read more

Function of the Deubiquitinating Enzyme USP46 in the Nervous System and Its Regulation by WD40-Repeat Proteins

Posttranslational modification of proteins by ubiquitin regulates synapse development and synaptic transmission.Much progress has been made investigating the role of ubiquitin ligases at the synapse, however very little is known about the deubiquitinating enzymes (DUBs) which remove ubiquitin from target proteins.Although there are far fewer DUBs t

read more